The MACRO Trial has now closed to recruitment.
The MACRO Trial has now closed to recruitment and has been published in The Lancet journal.
A lay summary of the publication is available to read or download from this link.
The trial is now in follow-up, and we thank all our participants for their ongoing engagement.
About MACRO Trial
The MACRO Trial is a randomised controlled trial (RCT) to produce evidence about the effectiveness and role of medical treatment (long-term antibiotics) and sinus surgery in adults with Chronic Rhinosinusitis (CRS) both with and without polyps.
The MACRO trial aimed to recruit 510 patients from at least 17 sites in the UK and began recruiting patients in Autumn 2018, closing to recruitment in late 2023.
The MACRO Trial is part of the MACRO Programme, which is made up of experts in sinus disease and breathing disorders, GPs, research experts and patient representatives. The programme is running in three sections of research over 7 years to establish the best treatment pathway for adults with CRS and ensure that this pathway is put into practice by GPs and hospital doctors. This should then make lives better for CRS patients and at the same time reduce ineffective use of healthcare resources within the NHS.
